医药微生物技术

张正

研究员
博士/硕士生导师
0532-58631557
个人简介 科研项目 学术论文 其他介绍

教育背景

2014.09-2018.06,bet365 코리아,微生物学,博士

2003.09-2007.06,bet365 코리아,国家生命科学与技术人才培养基地,本科


工作经历

2021.01-至今,bet365 코리아bet365 코리아,研究员,“齐鲁青年学者”,博导

2020.08-2021.01,bet365 코리아bet365 코리아,副研究员

2018.07-2020.07,bet365 코리아bet365 코리아,博士后

2007.07-2014.08,bet365 코리아,科研助理


研究方向

1.人工智能挖掘微生物功能基因资源

2.微生物生物地理学和群落生态学

3.微生物抗菌毒素-免疫蛋白系统

科研项目

1.国家自然科学基金面上项目,2023-2026,主持

2.科技部科技基础资源调查专项子课题,2022-2025,主持

3.bet365 코리아“齐鲁青年学者”学科建设经费,2021-2025,主持

4.江苏省自然科学基金青年基金项目,2019-2022,主持

5.中国博士后基金特别资助,2018-2020,主持

代表论文:

Li, D.1, Wang, J.1, Jiang, Y., Zhang, P., Liu, Y.,Li, Y. Z.*,&Zhang, Z.*(2024). Quantifying functional redundancy in polysaccharide‑degrading prokaryotic communities.Microbiome, 12: 120.(5 Year Impact Factor: 17.9)

Pan, Z.1, Li, D.1, Li, P., Geng, Y., Jiang, Y., Liu, Y., Li, Y. Z.*, &Zhang, Z.*(2024). GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere.Nucleic Acids Research, 52(D1): D724-D731.(5 Year Impact Factor: 16.1)

Li, D.1,Zhang, Z.1*, Zhang, P., Wang, J., Liu, Y., & Li, Y. Z.*(2024). Deterministic assembly processes shaping habitat‐specific glycoside hydrolase composition.Global Ecology and Biogeography, 33(1): 189-202.(5 Year Impact Factor: 7.7)

Liu, Y., Liu, S., Pan, Z., Ren, Y., Jiang, Y., Wang, F., Li, D.,Li, Y. Z.*,&Zhang, Z.*(2023). PAT: a comprehensive database of prokaryotic antimicrobial toxins.Nucleic Acids Research,51(D1): D452-D459.(5 Year Impact Factor: 16.1)

Li, D.,Zhang, Z.*, Wang, J., Zhang, P., Liu, Y., & Li, Y.Z.* (2023) Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities.Environmental Microbiology, 25(2): 397-409.(5 Year Impact Factor: 5.2)

Zhang, Z.1*, Liu, Y.1, Zhang, P., Wang, J., Li, D., & Li, Y. Z.*(2021). PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes.mSystems, 6(6): e00953-21. (5 Year Impact Factor: 6.1)

Li, D., Wang, J. L., Liu, Y., Li, Y. Z.*, &Zhang, Z.*(2021). Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases.Computational and Structural Biotechnology Journal, 19: 5931.(5 Year Impact Factor: 5.0)

Zhang, Z.1*, Wang, J.1, Wang, J., Wang, J., & Li, Y. Z.* (2020). Estimate of the sequenced proportion of the global prokaryotic genome.Microbiome,8: 134.(5 Year Impact Factor: 17.9)

Zhang, Z.1, Xing, C.1, Wang, L., Gong, B.*, & Liu, H. (2012). IndelFR: a database of indels in protein structures and their flanking regions.Nucleic Acids Research,40(D1): D512-D518.(5 Year Impact Factor: 16.1)

Zhang, Z., Huang, J., Wang, Z., Wang, L.*, & Gao, P. (2011). Impact of indels on the flanking regions in structural domains.Molecular Biology and Evolution,28(1): 291-301.(5 Year Impact Factor: 14.5)


其他论文:

Hu, W., Yang, J., Wang, J., Yuan, S., Yue, X.,Zhang, Z., Zhang, Y., Meng, J., & Li, Y. Z.*(2024). Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria.mSystems,9(6):e01210-23.(5 Year Impact Factor: 6.1)

Wang, J., Pan, Z., Yu, J.,Zhang, Z., & Li, Y. Z.* (2023). Global assembly of microbial communities.mSystems, 8(3): e01289-22.(5 Year Impact Factor: 6.1)

Ding, P., Ming, Z., Liu, J., Erill, I., &Zhang, Z.*(2022). Microbiome and microbial informatics.Frontiers in Microbiology, 4278.(5 Year Impact Factor: 5.1)

Zhang, P., Zhang, L., Jiang, X., Diao, X. T., Li, S., Li, D. D.,Zhang, Z., Fang, J., Tang Y. J., Wu, D. L., Wu, C., & Li, Y. Z. (2022). Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B.Communications Biology, 5(1): 1-11.(5 Year Impact Factor: 5.6)

Feng, Z.1,Zhang, Z.1,Liu, Y., Gu, J., Cheng, Y., Hu, W., Li, Y. Z., & Han, W.*(2021). The second chromosome promotes the adaptation of the genusFlammeovirgato complex environments.Microbiology Spectrum, 9(3): e00980-21. (5 Year Impact Factor: 4.2)

Wang, J.1, Wang, J.1, Wu, S.,Zhang, Z.*, & Li, Y. Z.*(2021). Global geographic diversity and distribution of the myxobacteria.Microbiology Spectrum, 9(1): e00012-21. (5 Year Impact Factor: 4.2)

Pan, Z.,Zhang, Z., Zhuo, L., Wan, T., & Li, Y. Z.*(2021). Bioinformatic and functional characterization of Hsp70s inMyxococcus xanthus.mSphere, 6(3): e00305-21. (5 Year Impact Factor: 4.0)

Liu, Y., Wang, J.,Zhang, Z., Wang, F.,& Li, Y. Z.*(2021). Two PAAR proteins with different C-terminal extended domains have distinct ecological functions inMyxococcus xanthus.Applied and Environmental Microbiology, 87(9): e00080-21.(5 Year Impact Factor: 4.6)

Liu, Y.,Zhang, Z.*, Wang, F., Li, D. D., & Li, Y. Z.* (2020). Identification of type VI secretion system toxic effectors using adaptors as markers.Computational and Structural Biotechnology Journal,18: 3723-3733.(5 Year Impact Factor: 5.0)

Zhang, P.1,Zhang, Z.1, Zhang, L., Wang, J., & Wu, C.* (2020). Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural features.Computational and Structural Biotechnology Journal,18: 1383-1390.(5 Year Impact Factor: 5.0)

Wang, J., Wang, J.,Zhang, Z., Li, Z., Zhang, Z., Zhao, D., ... & Li, Y. Z.* (2020). Shifts in the bacterial population and ecosystem functions in response to vegetation in the Yellow River delta wetlands.mSystems,5(3).(5 Year Impact Factor: 6.1)

Chen, X. J.,Zhang, Z., Li, Y. J., Zhuo, L., Sheng, D. H., & Li, Y. Z.* (2020). Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strainMyxococcus fulvus124B02.FEMS Microbiology Ecology,96(3): fiaa001.(5 Year Impact Factor: 4.2)

Li, D., Wang, J., Jin, Z., &Zhang, Z.*(2019). Structural and evolutionary characteristics of dynamin-related GTPase OPA1.PeerJ,7: e7285.(5 Year Impact Factor: 2.8)

Zhang, P.,Zhang, Z., Li, Z. F., Chen, Q., Li, Y. Y., Gong, Y., ... & Li, Y. Z.* (2019). Phylogeny‐guided characterization of glycosyltransferases for epothilone glycosylation.Microbial Biotechnology,12(4): 763-774.(5 Year Impact Factor: 5.8)

Zhang, Z., Wang, J., Gong, Y., & Li, Y. Z.* (2018). Contributions of substitutions and indels to the structural variations in ancient protein superfamilies.BMC Genomics,19(1): 1-9.(5 Year Impact Factor: 4.1)

Gong, Y.1,Zhang, Z.1, Liu, Y., Zhou, X. W., Anwar, M. N., Li, Z. S., ... & Li, Y. Z.* (2018). A nuclease‐toxin and immunity system for kin discrimination inMyxococcus xanthus.Environmental Microbiology,20(7): 2552-2567.(5 Year Impact Factor: 5.2)

Zhuo, L.,Zhang, Z., Pan, Z., Sheng, D. H., Hu, W., & Li, Y. Z.* (2018). CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicategroELs.Biochimica et Biophysica Acta-Gene Regulatory Mechanisms,1861(10): 928-937.(5 Year Impact Factor: 3.6)

Li, Y. J., Liu, Y.,Zhang, Z., Chen, X. J., Gong, Y., & Li, Y. Z.* (2018). A post-segregational killing mechanism for maintaining plasmid pMF1 in itsMyxococcus fulvushost.Frontiers in Cellular and Infection Microbiology,8: 274.(5 Year Impact Factor:5.1)

Gong, Y.,Zhang, Z., Zhou, X. W., Anwar, M. N., Hu, X. Z., Li, Z. S., ... & Li, Y. Z.* (2018). Competitive interactions between incompatible mutants of the social bacteriumMyxococcus xanthusDK1622.Frontiers in Microbiology,9: 1200. (5 Year Impact Factor: 5.1)

Yue, X. J.1, Cui, X. W.1,Zhang, Z., Hu, W. F., Li, Z. F., Zhang, Y. M., & Li, Y. Z.* (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones inMyxococcus xanthus.Applied Microbiology and Biotechnology,102(13): 5599-5610.(5 Year Impact Factor: 4.9)

Gao, X.*,Zhang, Z.*, Li, Y., Zhu, H., Wang, S., & Li, C. (2017). A newly determined member of the meso-diaminopimelate dehydrogenase family with a broad substrate spectrum.Applied and Environmental Microbiology,83(11).(5 Year Impact Factor: 4.6)

Liu, L.,Zhang, Z.*, Shao, C. L., & Wang, C. Y.* (2017). Analysis of the sequences, structures, and functions of product-releasing enzyme domains in fungal polyketide synthases.Frontiers in Microbiology,8: 1685. (5 Year Impact Factor: 5.1)

Yue, X. J., Cui, X. W.,Zhang, Z., Peng, R., Zhang, P., Li, Z. F., & Li, Y. Z.* (2017). A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis.Microbial Cell Factories,16(1): 1-12.(5 Year Impact Factor:5.5)

Zhuo, L.1, Wang, Y.1,Zhang, Z., Li, J., Zhang, X. H., & Li, Y. Z.* (2017).Myxococcus xanthusDK1622 coordinates expressions of the duplicategroELand singlegroESgenes for synergistic functions ofgroELsandgroES.Frontiers in Microbiology,8: 733. (5 Year Impact Factor: 5.1)

Peng, R., Chen, J. H., Feng, W. W.,Zhang, Z., Yin, J., Li, Z. S., & Li, Y. Z.* (2017). Error-prone DnaE2 balances the genome mutation rates inMyxococcus xanthusDK1622.Frontiers in Microbiology,8: 122. (5 Year Impact Factor: 5.1)

Wang, J.,Zhang, Z.*, Chang, F., & Yin, D.* (2016). Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15.PeerJ,4: e2079.(5 Year Impact Factor: 2.8)

Wang, J.1,Zhang, Z.1*, Liu, J., Zhao, J., & Yin, D.* (2016). Ectodomain architecture affects sequence and functional evolution of vertebrate toll-like receptors.Scientific Reports,6(1): 1-10.(5 Year Impact Factor: 4.3)

Liu, L.,Zhang, Z.*, Shao, C. L., Wang, J. L., Bai, H., & Wang, C. Y.* (2015). Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains.Scientific Reports,5(1): 1-12.(5 Year Impact Factor:4.3)

Wang, J.1,Zhang, Z.1*, Fu, H., Zhang, S., Liu, J., Chang, F., ... & Yin, D.* (2015). Structural and evolutionary characteristics of fish-specific TLR19.Fish & Shellfish Immunology,47(1): 271-279.(5 Year Impact Factor: 4.2)

Wang, J.,Zhang, Z.*, Liu, J., Li, F., Chang, F., Fu, H., ... & Yin, D.* (2015). Structural characterization and evolutionary analysis of fish-specific TLR27.Fish & Shellfish Immunology,45(2): 940-945.(5 Year Impact Factor: 4.2)

Wang, Y.1, Zhang, W. Y.1,Zhang, Z., Li, J., Li, Z. F., Tan, Z. G., ... & Li, Y. Z.* (2013). Mechanisms involved in the functional divergence of duplicated GroEL chaperonins inMyxococcus xanthusDK1622.PLoS Genet,9(2): e1003306.(5 Year Impact Factor: 4.9)

Zhang, Z., Wang, Y., Wang, L.*, & Gao, P.* (2010). The combined effects of amino acid substitutions and indels on the evolution of structure within protein families.PLoS One,5(12): e14316.(5 Year Impact Factor: 3.3)

2024年第十四届青岛市青年科技奖

Frontiers in Microbiology杂志Guest Associate EditorMicrobiome and Microbial Informatics专刊主编

2021年中国微生物学会学术年会 优秀学术报告

2021年Sino-Micro & ICMS年会Intestinal Microbiomes and Microbial Bioinformatics分会场主旨报告

2020年度bet365 코리아bet365 코리아“科研之星”